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Chondroitin Sulfate Sodium
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| Place of Origin | CHINA |
| Brand Name | HS |
| Certification | NSF-GMP |
| Model Number | 90% |
CPC 90% Chondroitin Sulfate Sodium with DMF documents for Joint health
Bovine Chondroitin sulfate sodium is extracted from the bovine cartilages with 90% content of chondroitin sulfate sodium by CPC Titration method, which conform to USP Standards.
Founded in 1997, Jiaxing Hengjie Biopharmaceutical Co., Ltd has been developed into a group company which provides the solution of Joint health ingredients to serve the customers all around the world. The subsidiary companies of Hengjie include Jiaxing Nudikon Lifescience Co., Ltd, Amnutra( China). Co., Ltd and HS Biopharmaceuticals, Inc. Hengjie established two quality devisions for food and drug industries
respectively to ensure the quality of products delivered to its valued customers.
The specification of bovine chondroitin sulfate sodium 90% by CPC Titration:
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ITEMS |
SPECIFICATIONS (TEST METHOD) |
RESULT |
| Appearance | White to off-white powder | Pass |
| Identification | Infra Red Confirmed (USP197K) | Pass |
| Sodium reaction (USP191) | Positive | |
| Assay(ODB) | NLT90% (CPC) | 92.4% |
| Loss on drying | Less than10%(USP731) | 8.8% |
| Protein | NMT6.0%(USP39) | 5.4% |
| Heavy Metal | NMT20PPM (MethodIIUSP231) | Pass |
| PH (1%H2O solution) | 5.5-7.5(USP791) | 6.2 |
| Chloride | NMT0.5%(USP221) | Pass |
| Sulfates | NMT0.24%(USP221) | Pass |
| Specific Rotation | - 20°~ -30°(USP781S) | -25.1° |
| Residue on Ignition | 20%-30%(USP281) | 23.5% |
| Clarity (5%H2O solution) | <0.35@420nm | 0.17 |
| Electrophoretic purity | NMT2.0%(USP726) | Pass |
| Total Bacteria Count | <1000CFU/g (USP2021) | Pass |
| Yeast & Mold | <100CFU/g (USP2021) | Pass |
| Salmonella | Negative (USP2022) | Negative |
| E.Coli | Negative (USP2022) | Negative |
| Staphylococcus Aureus | Negative (USP2022) | Negative |
| Particle size | 100% through 80 mesh | Pass |
The application of Bovine Chondroitin Sulfate Sodium:
1. The main application of chondroitin sulfate is joint health dietary supplements including Tablets, Capsules, and powder form.
2. Some bovine chondroitin sulfate is used to produce OTC Drugs in some countries (USA excluded)
3. Bovine chondroitin sulfate could also be used to produce eye drops or Cosmetics.
The Manufacturing Production Flow Chart of bovine chondroitin sulfate:
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Bovine Cartilages |
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Pre-treatment(cartilages selecting and washing) |
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Boiling ( add NACL,boil for 5 hours at the temperature of 90℃) |
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Enzymolysis (add pancreatin, add NAOH to adjust the PH value to 8.5-9.0, boil for 6 hours at the temperature of 48℃-50℃ |
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Flitration |
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First sedimentation(add ethanol to dissolve out the crude chondroitin sulfate) |
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Hydrolysis (add water and NACL,add NAOH to adjust PH value to about 9.0. Adjust temperature to 48℃-50℃ |
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Flitration |
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Second sedimentation(add ethanol to dissolve out purified chondroitin sulfate |
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Dehydration (add ethanol to dehydrate the water out of chondroitin sulfate |
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Centrifugation (get rid of ethanol) |
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Drying |
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Milling and Sifting |
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Blending (No other materials are added, just mixing) |
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Packing and testing |
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Chondroitin sulfate in 25KGS/drum |
The packing and Storage:
1. The packing is 25KG chondroitin sulfate is packed into Double PE bags and put into a fiber drum.
2. The chondroitin sulfate is extremely hygroscopic, avoid exposure to the air when unpacked the original package.
3. Packged into air tight PE bags,put into a fiber drum and then the drum in a cool and dry place, avoid direct sunshine exposure.
The photos of our GMP work shop:
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